This paper presents simulation analysis based on data from a real Smart Polygeneration Microgrid (SPM), designed to satisfy energy demands of the University Campus of Savona (Italy). The plant is made up of different generators (conventional, cogenerative, renewable) which are “distributed” around the campus and they are coupled to electrical and thermal storages. Since the system is constituted by co-generative prime movers it can supply both electrical and thermal energy of the campus and the integration of storage is really important in order to follow both the requests, pursuing the best management strategy.The analysis of this smart-grid is performed exploiting a software developed by the Author’s research group, which allows for the thermo-economic optimization of poly-generative energy systems. The software was used to find the best operational strategy showing the importance of an appropriate storage system to manage the grid taking into account its polygenerative features, analyzing the integration and the combination of three different kind of storage: hot water tank, cold water tank, electrical battery. Different scenarios are presented combining the three storages and showing the impact of them in terms of money savings and reduction of the purchasing of electricity from the National grid. These scenarios were analyzed both considering an interconnection with the national electrical grid and to operate the SPM in-island mode.